"Wonderful Precure!" centers around a young girl named Iroha Inukai, who moves to Animal Town with her family. The town is unique for its harmonious coexistence between humans and anthropomorphic animals. Iroha quickly befriends Komugi, a cheerful and energetic puppy, and together they encounter a mysterious creature named Mayu, who is being pursued by the villainous organization known as the Nometes. The Nometes aim to disrupt the peace of Animal Town by spreading negative energy and transforming innocent creatures into monstrous forms.

Iroha and Komugi discover they have the ability to transform into the legendary warriors known as Precure, tasked with protecting the town and its inhabitants. As Precure, they gain magical powers and must work together to combat the Nometes and their minions. Along the way, they are joined by other allies, including Yuki, a reserved but kind-hearted cat, and Sora, a brave and determined bird. Each character brings unique strengths and perspectives to the team, enhancing their ability to face the growing threats.

The narrative explores themes of friendship, courage, and the importance of understanding and cooperation between different beings. The Precure team must navigate various challenges, both in their battles against the Nometes and in their personal lives, as they strive to maintain the balance and harmony of Animal Town. The series balances action-packed sequences with moments of heartfelt interaction, emphasizing the bonds between the characters and their shared commitment to protecting their home.