"Real Girl" is a romantic drama anime that centers on the relationship between Hikari Tsutsui, a socially awkward high school student, and Iroha Igarashi, a popular and outgoing girl. Hikari is an introverted otaku who spends most of his time immersed in anime, manga, and video games, leading to his isolation from his peers. His life takes an unexpected turn when Iroha, who is often seen as a "delinquent" due to her bold personality and rumored promiscuity, begins to show interest in him. Despite their contrasting personalities, the two form an unlikely bond and eventually start dating.

The series explores the challenges and growth that come with their relationship. Hikari struggles to navigate the complexities of real-world romance, often feeling insecure and out of his depth. Iroha, on the other hand, harbors her own vulnerabilities, including a strained relationship with her family and a fear of being misunderstood. As their relationship deepens, both characters confront their insecurities and learn to support each other. The narrative also delves into the dynamics of their friendships, particularly Hikari's interactions with his childhood friend, Ayado, and Iroha's connections with her peers.

Throughout the series, themes of self-acceptance, communication, and the transformative power of love are prominent. The story balances moments of lighthearted humor with emotional depth, portraying the ups and downs of young love. Secondary characters, such as Hikari's younger sister and Iroha's friends, add layers to the narrative, providing additional perspectives on the central relationship. The anime concludes with a focus on the growth of both protagonists, emphasizing the importance of understanding and empathy in overcoming personal and relational challenges.