"O Maidens in Your Savage Season" centers on a group of high school girls navigating the complexities of adolescence, relationships, and self-discovery. The story revolves around the members of the school's literature club, each grappling with their burgeoning sexuality and emotional turmoil. Kazusa Onodera, the protagonist, is a reserved and introspective girl who begins to question her feelings after reading a novel that explores themes of love and desire. Her best friend, Hitoha Hongou, is a sharp and pragmatic writer who often masks her own insecurities with wit and sarcasm. Niina Sugawara, another member of the club, is more openly curious about romance and sexuality, often pushing boundaries and challenging societal norms. Momoko Sudou, the club's president, struggles with her conservative upbringing and her growing attraction to a male classmate, while Izumi Norimoto, the only male member of the club, finds himself caught in the middle of the girls' emotional entanglements.

The narrative unfolds as the girls confront their fears, desires, and misunderstandings about love and intimacy. Kazusa's crush on her childhood friend, Izumi, becomes a central focus, complicated by her inexperience and the interference of others. Niina's boldness leads to a series of provocative encounters, forcing her to confront the consequences of her actions. Hitoha's writing serves as both an escape and a mirror to her inner conflicts, while Momoko's struggle to reconcile her feelings with her upbringing creates tension within the group. The series explores themes of identity, communication, and the often messy process of growing up, portraying the girls' experiences with a mix of humor, poignancy, and raw honesty. Through their interactions and personal journeys, the characters gradually come to understand themselves and each other, highlighting the universal challenges of adolescence.