"ORESUKI: Are you the only one who loves me?" centers around Joro, a high school student who presents himself as a kind and accommodating person to maintain his popularity. Beneath this facade, however, he harbors a cynical and self-serving attitude, often manipulating situations to his advantage. His life takes a dramatic turn when he receives confessions from two girls: his childhood friend, Sakura "Cosmos" Akino, and the quiet, bookish Sumireko "Pansy" Sanshokuin. Joro initially believes he is living a romantic dream, but his expectations are shattered when he discovers that both confessions were orchestrated to manipulate him into helping them pursue his best friend, Taiyo Oga.

As the story unfolds, Joro's interactions with these characters reveal deeper layers of their personalities and motivations. Pansy, in particular, emerges as a central figure, displaying a sharp wit and an uncanny ability to see through Joro's facade. Her persistent presence and cryptic remarks suggest she knows more about Joro than she lets on, creating an air of mystery around her intentions. Meanwhile, Cosmos struggles with her feelings for Oga and her growing awareness of Joro's true nature.

The narrative explores themes of deception, self-awareness, and the complexities of human relationships. Joro's attempts to navigate his romantic entanglements are often thwarted by his own flaws and the unpredictable actions of those around him. The series balances comedic moments with dramatic tension, as Joro's schemes frequently backfire, forcing him to confront his insecurities and the consequences of his actions.

Supporting characters, such as the cheerful and athletic Himawari and the stoic librarian Tsubaki, add further depth to the story, each contributing to the web of misunderstandings and emotional conflicts. The dynamic between the characters drives the plot forward, with Joro's relationships evolving in unexpected ways as he grapples with his own identity and the true nature of love and friendship. The series concludes with a mix of resolution and open-endedness, leaving room for interpretation regarding the characters' futures.