"Fusé: Memoirs of a Huntress" is set in an alternate version of Japan's Edo period, where humans coexist with shape-shifting beings known as Fusé. These creatures, capable of transforming into animals, are hunted by humans due to their perceived threat and the valuable pelts they leave behind upon death. The story centers on Hamaji, a young girl from a remote mountain village, who becomes entangled in the conflict between humans and Fusé after encountering a mysterious and powerful Fusé named Shino.

Shino, a wolf-like Fusé, is captured by humans and brought to Edo, where he is subjected to cruel experiments and exploitation. Hamaji, driven by a mix of curiosity and compassion, forms a bond with Shino and resolves to help him escape. As their relationship deepens, Hamaji begins to question the morality of hunting Fusé and the broader societal prejudices that fuel the conflict. The narrative explores themes of coexistence, identity, and the consequences of fear-driven violence.

The story also delves into the lives of other key characters, such as the Fusé hunter Hyakkimaru, who views Fusé as nothing more than prey, and the enigmatic Fusé leader, who seeks to protect his kind from human persecution. The tension between humans and Fusé escalates as both sides grapple with their mutual distrust and the cycle of violence perpetuated by their actions. Hamaji's journey becomes a catalyst for challenging the status quo, as she navigates the complexities of loyalty, morality, and the possibility of reconciliation between the two species.

The plot unfolds with a blend of action, drama, and introspection, as characters confront their own beliefs and the harsh realities of their world. The series balances moments of intense conflict with quieter, reflective scenes that highlight the emotional and ethical dilemmas faced by its protagonists. Through its exploration of the human-Fusé dynamic, "Fusé: Memoirs of a Huntress" presents a thought-provoking narrative that examines the consequences of prejudice and the potential for understanding between seemingly irreconcilable groups.