"Sora o Miageru Shōjo no Hitomi ni Utsuru Sekai" is a 12-episode anime series that blends elements of fantasy, drama, and science fiction. The story is set in a world where humanity is under constant threat from mysterious, otherworldly beings known as "Tartaros." To combat these threats, humanity relies on a group of young girls called "Orphans," who possess the ability to summon powerful entities known as "Elements" to fight the Tartaros. These Orphans are trained and guided by an organization called "Alvis," which operates from a floating fortress called "Mithril."

The protagonist, Kazuya, is a young boy who becomes involved with Alvis after his sister, Misao, is chosen as an Orphan. Misao, however, struggles with the emotional and psychological toll of her role, as the process of summoning Elements requires a deep emotional connection, often leading to personal sacrifice. Kazuya, determined to protect his sister, becomes deeply entwined in the operations of Alvis and the lives of the other Orphans. Among them is Nayeli, a skilled and confident Orphan who serves as a mentor figure, and Itsuki, a reserved and introspective girl who harbors her own emotional burdens.

As the series progresses, the narrative explores the relationships between the Orphans and their Elements, delving into themes of identity, loss, and the cost of power. The Orphans must confront not only the external threat of the Tartaros but also their internal struggles, as the line between their humanity and their roles as weapons begins to blur. The story takes a dramatic turn when it is revealed that the Tartaros are not merely mindless invaders but are connected to the Orphans in ways that challenge the very foundation of Alvis's mission.

The series builds toward a climactic confrontation where the true nature of the Tartaros and the purpose of the Orphans are unveiled. The resolution of the story hinges on the choices made by Kazuya, Misao, and the other Orphans as they grapple with their destinies and the consequences of their actions. The narrative concludes with a mix of hope and melancholy, leaving the fate of the characters and their world open to interpretation.