"Alexander: The Movie" is an anime adaptation that chronicles the life and conquests of Alexander the Great, one of history's most renowned military leaders. The narrative begins with Alexander's early years in Macedonia, highlighting his education under the tutelage of Aristotle and his complex relationship with his father, King Philip II. The story emphasizes Alexander's ambition and strategic brilliance, traits that propel him to ascend the throne after Philip's assassination.

The plot follows Alexander's rapid expansion of the Macedonian Empire, detailing his military campaigns across Persia, Egypt, and into the Indian subcontinent. Key battles, such as the decisive clash at Gaugamela against Darius III of Persia, are depicted with a focus on Alexander's innovative tactics and leadership. The anime also explores his interactions with notable figures, including his loyal general Hephaestion, his rival and eventual ally King Porus of India, and his contentious relationship with his own troops as they grow weary of endless conquest.

Themes of ambition, legacy, and the burdens of leadership are central to the narrative. Alexander's vision of uniting diverse cultures under a single empire is portrayed alongside the personal costs of his relentless drive. The anime delves into his internal struggles, including his growing isolation and the psychological toll of his ambitions. The story concludes with Alexander's untimely death in Babylon, leaving his empire fragmented and his legacy a subject of historical debate.

The main characters include Alexander himself, depicted as a charismatic yet flawed leader; Hephaestion, his closest companion and confidant; and Roxana, his wife, who represents his efforts to bridge cultural divides. Historical figures such as Aristotle, Darius III, and King Porus are also integral to the narrative, providing context and conflict to Alexander's journey. The anime balances historical accuracy with dramatic storytelling, offering a comprehensive portrayal of Alexander's life and the era he shaped.