"Re: Cutie Honey" is a three-episode OVA series that reimagines the classic 1970s magical girl story "Cutie Honey" with a modern twist. The narrative centers on Honey Kisaragi, a high school girl who is secretly an android created by her late father, Dr. Kisaragi. Honey possesses the ability to transform into the superheroine Cutie Honey using the "Airborne Element Fixing Device," which allows her to alter her molecular structure and adopt various forms, including her iconic armored warrior guise. Her mission is to protect humanity from the criminal organization Panther Claw, led by the enigmatic Sister Jill, who seeks to harness Honey's transformative technology for nefarious purposes.

The story begins with Honey living a seemingly ordinary life as a student, but her world is upended when Panther Claw attacks her school, revealing her true identity and forcing her into action. Throughout the series, Honey battles a series of Panther Claw's agents, each with unique abilities and grotesque designs, while uncovering the truth about her origins and the motivations of Sister Jill. The narrative explores themes of identity, sacrifice, and the struggle between good and evil, as Honey grapples with her dual existence as both a human-like android and a protector of justice.

Supporting characters include Natsuko Aki, a journalist and Honey's close friend, who becomes a key ally in her fight against Panther Claw, and Seiji Hayami, a police inspector who aids Honey in her missions while harboring suspicions about her true nature. The series blends action, comedy, and drama, with fast-paced battles and moments of emotional depth as Honey confronts the moral complexities of her role as a hero. The OVA concludes with a climactic showdown between Honey and Sister Jill, resolving the central conflict while leaving room for further exploration of Honey's journey.