"Cuticle Detective Inaba" is a comedic action anime centered around Hiroshi Inaba, a detective with the unique ability to extract information from hair. Inaba, a former werewolf, now operates as a private investigator with his assistant, Yuuta. His primary adversary is Don Valentino, a goat-like crime boss with a penchant for elaborate schemes. Don Valentino’s gang, including the loyal and often bumbling Keiji, frequently clashes with Inaba as he attempts to thwart their criminal activities.

The narrative unfolds through episodic cases, blending absurd humor with detective work. Inaba’s hair-based abilities, which allow him to analyze and even manipulate individuals through their hair, serve as a recurring plot device. These cases often involve bizarre scenarios, such as tracking down stolen gold or uncovering the secrets behind mysterious hair-related phenomena. Despite the comedic tone, the series occasionally delves into darker themes, particularly through flashbacks revealing Inaba’s past as a werewolf and his connection to Don Valentino.

The supporting cast includes a range of eccentric characters, such as the stoic and sharp-shooting police officer Ogino, who frequently collaborates with Inaba, and the genetically engineered cross-dressing wolf, Keiji, whose loyalty to Don Valentino is both comical and tragic. The dynamic between Inaba and Don Valentino is a central focus, with their rivalry driving much of the plot. While the series maintains a lighthearted atmosphere, it occasionally explores themes of identity, loyalty, and redemption, particularly through the interactions between Inaba and his adversaries.

The anime’s episodic structure allows for a mix of standalone cases and overarching storylines, with the latter gradually revealing more about the characters’ backstories and motivations. The blend of slapstick comedy, detective intrigue, and occasional emotional depth creates a distinctive tone, making "Cuticle Detective Inaba" a unique entry in the detective genre. The series balances its absurd premise with a focus on character relationships, ensuring that the humor and action remain grounded in the personalities and conflicts of its cast.