"Murder Princess" is a six-episode anime OVA series that blends action, fantasy, and science fiction elements. The story begins with Princess Alita Forland fleeing her kingdom after a coup led by her father's trusted advisor, Dr. Akamashi, who seeks to harness the power of forbidden technology. During her escape, Alita encounters Falis, a skilled bounty hunter, in a forest. A magical accident causes their souls to switch bodies, leaving Alita in Falis's body and Falis in Alita's. Falis, now in the princess's body, reluctantly agrees to protect the kingdom in exchange for Alita's assistance in reclaiming her original form.

Falis, possessing immense combat prowess, takes on the role of the "Murder Princess" and vows to defend the kingdom from Dr. Akamashi's forces, which include genetically engineered monsters and rogue soldiers. Alita, though physically weaker in Falis's body, provides moral support and strategic insight. The series explores their evolving dynamic as they navigate their shared predicament and confront external threats. Supporting characters include Pete Armstrong, a loyal knight who aids Falis, and Dominikov, a mysterious assassin with ties to Falis's past.

The plot unfolds through a series of battles and revelations, culminating in a confrontation with Dr. Akamashi, who seeks to use ancient technology to achieve immortality and domination. The narrative balances action sequences with moments of character development, particularly focusing on Falis's internal struggle with her identity and Alita's growth as a leader. The series concludes with a resolution to the conflict, though the aftermath leaves room for reflection on the characters' journeys and the consequences of their choices.