"Amaenaide yo!! Katsu!!" is a comedic supernatural anime series centered around the lives of a group of young nuns-in-training at the Saienji Temple. The protagonist, Ikkou Satonaka, is a novice monk with a peculiar condition: whenever he is exposed to sexual stimuli, he transforms into a powerful exorcist capable of banishing evil spirits. This ability, while useful, often leads to awkward and humorous situations due to the nature of its activation.

The series primarily revolves around the daily lives of Ikkou and the six nuns—Sumi Ikuina, Haruka Amanogawa, Kazuko Kawashima, Tomoko Inui, Chitose Nanbu, and Hibiki Amakawa—as they train to become full-fledged nuns. Their training involves not only spiritual and physical discipline but also combating malevolent spirits that threaten the temple and its surroundings. The nuns, each with distinct personalities and quirks, frequently find themselves in comedic and chaotic scenarios, often involving Ikkou's accidental transformations.

The narrative is episodic, with each episode typically featuring a new supernatural threat or a comedic situation arising from the characters' interactions. The series balances lighthearted humor with moments of action and exorcism, creating a blend of comedy and supernatural elements. The dynamic between Ikkou and the nuns is a central focus, with their relationships evolving through various misadventures and challenges.

While the primary tone is comedic, the series occasionally delves into the characters' backstories and motivations, providing depth to their personalities. The nuns' dedication to their training and their camaraderie are recurring themes, as is Ikkou's struggle to control his powers and fulfill his duties as a monk. The interplay between the characters' personal growth and the episodic nature of the plot drives the series forward, maintaining a balance between humor and character development.