"Fastest Finger First" centers on Shiki Koshiyama, a high school student with a deep passion for quiz competitions. Shiki's journey begins when he joins his school's quiz bowl club, where he discovers a competitive world that challenges his knowledge, reflexes, and strategic thinking. The series explores the intricacies of quiz bowl tournaments, emphasizing the importance of quick recall, teamwork, and mental agility.

Shiki is portrayed as an introverted yet highly intelligent individual who thrives in the structured environment of quiz competitions. His analytical mind and ability to recall obscure facts make him a formidable competitor. Alongside Shiki is Mari Fukami, a confident and outgoing teammate who complements his reserved nature. Their dynamic highlights the balance between individual strengths and collaborative effort, a recurring theme throughout the series.

The narrative progresses through various quiz bowl matches, each presenting unique challenges and opponents. The competitions are depicted with a focus on the tension and excitement of timed questions, buzzer strategies, and the psychological pressure of high-stakes tournaments. The series also delves into the personal growth of the characters, particularly Shiki, as he learns to overcome his insecurities and embrace his passion for quizzing.

Supporting characters, such as Gakuto Sasajima and Chisato Mikuriya, add depth to the story by representing different approaches to competition and knowledge. Gakuto, a seasoned quizzer, serves as a mentor figure, while Chisato's calm demeanor and sharp intellect provide a contrast to Shiki's intensity. The interplay between these characters enriches the narrative, showcasing the diverse motivations and backgrounds that drive individuals to excel in quiz bowl.

"Fastest Finger First" balances its competitive elements with moments of camaraderie and self-discovery. The series effectively captures the thrill of intellectual competition while exploring themes of perseverance, self-confidence, and the value of teamwork. Through its engaging portrayal of quiz bowl culture, the anime offers a unique perspective on the challenges and rewards of pursuing one's passions.