"The Masterful Cat Is Depressed Again Today" centers on the daily life of Saku Fukuzawa, a young office worker, and her extraordinary house cat, Yukichi. Yukichi is no ordinary feline; he stands over six feet tall, walks on two legs, and possesses human-like intelligence. Despite his imposing appearance, Yukichi is a gentle and nurturing figure who takes on the role of managing Saku’s household. He cooks, cleans, shops, and even offers emotional support, effectively running the home while Saku struggles with her chaotic and often lazy lifestyle.

Saku, though appreciative of Yukichi’s efforts, often takes his domestic prowess for granted. Her disorganized habits and tendency to overwork herself create a dynamic where Yukichi frequently steps in to ensure her well-being. The series humorously explores their unconventional relationship, highlighting Yukichi’s dedication and occasional exasperation with Saku’s carelessness. Despite his occasional bouts of melancholy, Yukichi remains a steadfast and loving presence in Saku’s life.

The narrative unfolds in a slice-of-life format, with each episode presenting vignettes of their daily routines and interactions. The series delves into themes of companionship, responsibility, and the balance of dependence and independence. Secondary characters, such as Saku’s coworkers and acquaintances, occasionally appear, adding variety to the story while maintaining the focus on the central duo. The interplay between Saku’s human flaws and Yukichi’s almost superhuman competence creates a charming and heartwarming dynamic, making the series a lighthearted yet meaningful exploration of everyday life with a fantastical twist.