"Cream Lemon" is an anthology series consisting of multiple standalone episodes, each featuring different characters and storylines, often centered around themes of romance, drama, and adult relationships. The series does not follow a continuous narrative but instead explores various scenarios, ranging from lighthearted romantic encounters to more complex and emotionally charged situations.

One of the recurring story arcs involves a young couple, Ami and her boyfriend, navigating the challenges of their relationship. Their story delves into themes of love, jealousy, and personal growth, often highlighting the emotional struggles that come with young romance. Another notable arc focuses on a schoolgirl named Kurumi, who becomes entangled in a complicated relationship with her teacher, exploring themes of power dynamics and forbidden love.

The series also includes episodes with supernatural or fantastical elements, such as a story about a mysterious girl with telekinetic powers who forms a bond with a young man. These episodes often blend romance with elements of science fiction or fantasy, adding variety to the anthology.

Throughout the series, the characters are portrayed with a focus on their emotional depth and interpersonal relationships, often emphasizing the consequences of their actions and decisions. The storytelling varies in tone, with some episodes leaning toward melodrama while others adopt a more lighthearted or surreal approach.

While the series is known for its adult themes and explicit content, it also attempts to explore the psychological and emotional dimensions of its characters, providing a mix of entertainment and introspection. The lack of a continuous narrative allows each episode to stand on its own, offering viewers a diverse range of stories and experiences.