In a dystopian future where war has been eradicated through the use of hypnosis technology, Japan is divided into four territories: Ikebukuro, Yokohama, Shibuya, and Shinjuku. Each territory is governed by a rap group that uses their words and music as weapons in verbal battles known as "Rap Battles." These battles, powered by Hypnosis Microphones, allow users to channel their emotions and convictions into powerful sonic attacks. The central conflict arises when the government, seeking to maintain control, pits these groups against each other in a high-stakes competition to determine the dominant territory.

The story primarily revolves around the four rap crews: Buster Bros!!! from Ikebukuro, led by the hot-headed Ichiro Yamada and his younger brothers Jiro and Saburo; Mad Trigger Crew from Yokohama, consisting of the stoic Samatoki Aohitsugi, the enigmatic Rio Mason Busujima, and the unpredictable Jyuto Iruma; Fling Posse from Shibuya, featuring the flamboyant Ramuda Amemura, the calculating Gentaro Yumeno, and the energetic Dice Arisugawa; and Matenrou from Shinjuku, composed of the enigmatic Doppo Kannonzaka, the reserved Hifumi Izanami, and their leader, the mysterious Jakurai Jinguji. Each crew has its own motivations, backstories, and philosophies, which are gradually revealed as the narrative unfolds.

As the Rap Battles escalate, tensions rise between the groups, and alliances are tested. The government's manipulation becomes increasingly apparent, with hints of a larger conspiracy involving the origins of the Hypnosis Microphones and the true purpose of the battles. The characters are forced to confront their pasts, their relationships, and their own convictions as they navigate the complex web of power struggles and personal conflicts. The series balances intense rap battles with moments of character development, exploring themes of loyalty, identity, and the power of words.

The narrative structure alternates between high-energy rap battles and quieter, introspective moments that delve into the characters' histories and motivations. The battles themselves are visually dynamic, with each crew's unique style and personality reflected in their performances. The series also incorporates elements of mystery and intrigue, as the true nature of the government's agenda and the origins of the Hypnosis Microphones are gradually uncovered.

Overall, "Hypnosis Mic -Division Rap Battle- Rhyme Anima+" presents a unique blend of music, action, and drama, set against a backdrop of political intrigue and personal struggle. The series offers a compelling exploration of its characters and their world, driven by the central premise of rap as both a weapon and a means of self-expression.