"AIR TV" is a 12-episode anime series based on the visual novel by Key. The narrative revolves around Yukito Kunisaki, a traveling performer who seeks the "Girl in the Sky," a figure from his family's legends. His journey leads him to a small coastal town where he meets Misuzu Kamio, a peculiar and lonely girl with a mysterious illness. Yukito stays with Misuzu and her adoptive mother, Haruko, while continuing his search. Misuzu's condition worsens over time, and her dreams reveal fragments of a past life connected to a tragic legend involving a winged girl named Kanna.

The story intertwines the present with flashbacks to a distant past, where Kanna, a girl with wings, is imprisoned and isolated due to her unique nature. Her only companion is Ryuuya, a guard who befriends her. Their bond grows, but Kanna's fate is tied to a curse that affects her lineage. In the present, Misuzu's connection to Kanna becomes evident as her dreams and memories blur the lines between her identity and Kanna's. Yukito discovers that Misuzu is a reincarnation of Kanna, and her illness is a manifestation of the curse.

As the narrative progresses, Yukito learns that the curse can only be broken by severing the ties between Misuzu and Kanna's past. This involves confronting the emotional and spiritual burdens carried across generations. The series explores themes of sacrifice, love, and the cyclical nature of suffering, culminating in a bittersweet resolution where Misuzu's fate is sealed, but her spirit finds peace.

Other characters include Minagi Tohno, a stoic girl with a troubled family life, and Kano Kirishima, a cheerful yet enigmatic girl who harbors her own secrets. Their stories intersect with Yukito and Misuzu's, adding depth to the overarching narrative. The series balances its supernatural elements with poignant human drama, creating a layered and emotionally resonant tale.