"Princess Princess" is a 12-episode anime series based on the manga by Mikiyo Tsuda. The story is set in an all-boys high school, Fujimori Academy, which has a unique tradition to boost morale and maintain a sense of balance among its students. Three male students are selected each year to serve as "Princesses," dressing in female uniforms and participating in school events to provide a sense of cheer and inspiration to their peers. The tradition is seen as a way to counteract the monotony of an all-male environment and is highly regarded within the school.

The narrative centers around three first-year students: Toru Kouno, Yuujirou Shihoudani, and Mikoto Yutaka, who are chosen to become the new Princesses. Toru, a cheerful and easygoing student, initially struggles with the idea of cross-dressing but eventually embraces the role. Yuujirou, a reserved and serious individual, reluctantly accepts the position due to his family's financial ties to the school. Mikoto, a quiet and introverted boy, is chosen for his delicate appearance and quickly becomes a fan favorite among the student body. Together, the trio navigates the challenges and responsibilities of their roles while forming close bonds with each other.

The series explores their daily lives as they balance their academic responsibilities with their duties as Princesses. They participate in various school events, such as festivals and sports days, often becoming the center of attention. Their interactions with other students, including upperclassmen and members of the student council, add depth to the story. The series also delves into the personal backgrounds of the main characters, revealing their motivations and struggles. Toru's past as a former delinquent, Yuujirou's family pressures, and Mikoto's insecurities about his appearance are gradually uncovered, providing context for their actions and growth throughout the series.

While the premise is lighthearted and comedic, the anime also touches on themes of identity, self-expression, and the importance of camaraderie. The relationships between the Princesses and their peers evolve over time, highlighting the impact of their roles on the school community. The series maintains a balance between humor and heartfelt moments, creating an engaging narrative that appeals to a wide audience. The characters' development and the exploration of their individual and collective experiences form the core of the story, making "Princess Princess" a memorable addition to the school-life genre.