"Re:CREATORS" is a 22-episode anime series that blends elements of fantasy, action, and meta-fiction. The narrative centers on the collision of fictional worlds with reality, exploring the consequences when characters from various stories are brought into the real world. The protagonist, Sota Mizushino, is a high school student and aspiring creator who becomes entangled in this phenomenon after encountering Selesia Upitiria, a heroine from his favorite light novel series, "Elemental Symphony of Vogelchevalier." Selesia is one of several "Creations"—fictional characters who have been transported to the real world by a mysterious force.

The catalyst for this event is a character named Altair, a powerful and enigmatic Creation who originates from a fan-made video. Altair seeks to reshape reality, believing that the real world has mistreated its creators and their works. Her actions threaten to destabilize both the fictional and real worlds, prompting a coalition of Creations and their creators to unite against her. The series delves into the relationships between creators and their creations, examining themes of authorship, responsibility, and the impact of storytelling on both individuals and society.

Key characters include Meteora Österreich, a calm and analytical librarian from a fantasy RPG, and Mamika Kirameki, a magical girl with a strong sense of justice. Other notable Creations include Alicetelia February, a stoic knight from a war-torn fantasy world, and Rui Kanoya, a mecha pilot from a sci-fi series. On the human side, Marine, the creator of Selesia, and Matsubara, the author of Alicetelia's story, play significant roles in guiding and supporting their respective characters.

The plot unfolds as the Creations and their creators collaborate to understand Altair's motives and devise a strategy to stop her. The series balances intense action sequences with introspective moments, highlighting the emotional and philosophical dilemmas faced by both the Creations and their creators. As the conflict escalates, the boundaries between fiction and reality blur, raising questions about the nature of existence and the power of creative expression. The narrative culminates in a climactic confrontation that tests the resolve of all parties involved, ultimately resolving the crisis while leaving room for reflection on the enduring connection between creators and their works.