"Little Princess Sara" is a 46-episode anime series based on Frances Hodgson Burnett's novel "A Little Princess." Set in late 19th-century London, the story centers on Sara Crewe, a young girl born to a wealthy British family in India. After her mother's death, Sara is sent to the prestigious Minchin Seminary for Girls in London, where her father enrolls her while he returns to India to manage his business. Sara's intelligence, kindness, and vivid imagination quickly make her a beloved figure among her classmates, though her privileged background also draws envy and resentment from some, including the strict and domineering headmistress, Miss Minchin.

Sara's life takes a dramatic turn when she receives news of her father's death and the loss of his fortune. Stripped of her status and possessions, Sara is forced into servitude at the seminary, enduring harsh treatment from Miss Minchin and her jealous peers. Despite her circumstances, Sara maintains her dignity and resilience, drawing strength from her imagination and the friendships she has cultivated, particularly with the kind-hearted maid Becky and her loyal friend Ermengarde. Her ability to find beauty and hope in adversity inspires those around her, even as she struggles with loneliness and hardship.

The narrative explores themes of class disparity, resilience, and the power of kindness. Sara's unwavering optimism and belief in the inherent goodness of people stand in stark contrast to the cruelty and greed she encounters. Over time, her fortunes begin to shift as secrets about her father's legacy come to light, leading to a resolution that restores her rightful place while reinforcing the moral lessons of compassion and perseverance. The series balances moments of emotional depth with lighter, whimsical elements, capturing the essence of Sara's imaginative spirit and the challenges she faces in a rigid, often unforgiving society.