"Osomatsu-san ~Hipipo-Zulu to Kagayaku Kajitsu~" is a comedic anime series that serves as a modern revival of the classic 1960s manga and anime "Osomatsu-kun." The story revolves around the Matsuno sextuplets: Osomatsu, Karamatsu, Choromatsu, Ichimatsu, Jyushimatsu, and Todomatsu. These six brothers, now in their twenties, are perpetually unemployed and spend their days engaging in absurd, chaotic antics that often spiral into surreal and unpredictable situations. The series is episodic, with each episode featuring self-contained stories that highlight the brothers' dysfunctional dynamics and their interactions with a colorful cast of supporting characters.

The Matsuno brothers are characterized by their distinct personalities. Osomatsu, the eldest, is lazy and mischievous, often leading the group into trouble. Karamatsu fashions himself as a cool and romantic figure, though his attempts at being suave are frequently met with ridicule. Choromatsu is the most responsible and self-aware, often exasperated by his brothers' behavior. Ichimatsu is introverted and cynical, with a penchant for stray cats. Jyushimatsu is eccentric and hyperactive, embodying a childlike sense of wonder. Todomatsu, the youngest, is manipulative and image-conscious, often scheming to improve his social standing.

The series thrives on its absurd humor, breaking the fourth wall, and satirizing various aspects of Japanese culture, media, and societal norms. The brothers frequently find themselves in bizarre scenarios, ranging from attempting to find jobs or romantic partners to participating in nonsensical competitions or encountering supernatural phenomena. The supporting cast includes characters like Iyami, a recurring antagonist with a signature catchphrase, and Totoko, a popular girl who often becomes the object of the brothers' affections.

"Osomatsu-san ~Hipipo-Zulu to Kagayaku Kajitsu~" maintains a fast-paced, irreverent tone, blending slapstick comedy with sharp wit and meta-commentary. The narrative structure is loose, allowing for a wide range of comedic styles and parodies, often referencing other anime, pop culture, and even its own legacy as a revival of a classic series. The series balances its humor with occasional moments of introspection, exploring the brothers' insecurities and the challenges of growing up in a society that expects them to conform. Despite their flaws, the Matsuno brothers' camaraderie and shared experiences form the emotional core of the series, making their misadventures both entertaining and relatable.