Paolo De Santis is an Italian voice actor, born in Milan on January 17, 1979. He is primarily known for his extensive work dubbing foreign productions into Italian, including a vast number of anime series and films. He grew up in Milan and studied at the Centro Teatro Attivo (CTA) in the city, where he trained in diction, acting, and dubbing. His career as a voice actor began after this formal training, and he now works between Milan and Rome.

De Santis is the official Italian voice for numerous characters in popular anime. His roles are diverse and include protagonist characters as well as memorable supporting roles. Some of his most notable anime dubbing credits include Korosensei in Assassination Classroom, Shinji Matou in the Fate/stay night series, Professor Kukui in Pokémon Sun & Moon, Atsumu Yukiatsu Matsuyuki in Anohana: The Flower We Saw That Day, and Stitch in the Italian-language version of the Stitch! series. He has also voiced characters in long-running and globally popular series such as One Piece, where he has taken on multiple roles including Gol D. Roger and Crocodile, Kiba Inuzuka in Naruto and Naruto: Shippuden, Yusei Fudo in Yu-Gi-Oh! 5D's, and Ryuga in Beyblade Metal Fusion. His film work includes dubbing for animated features like the Frozen films, where he is the voice of Kristoff, and various entries in the Fate/stay night: Heaven's Feel movie trilogy.

Beyond anime, De Santis has a prolific career in dubbing for live-action film and television, as well as video games. He is the Italian voice for actor Oscar Isaac in several films and has dubbed characters in major video game franchises, notably as the voice of Altaïr Ibn-La'Ahad in the first Assassin's Creed game and Booker DeWitt in BioShock Infinite. He has also been the official promotional voice for the Italian TV channel Comedy Central since 2007.