"Comic Party" centers on Kazuki Sendou, a high school student who is drawn into the world of doujinshi (self-published works) after being introduced to it by his friend Taishi Kuhonbutsu. Initially hesitant, Kazuki becomes increasingly involved in the doujinshi scene, attending conventions and collaborating with other creators. The series explores his journey as he navigates the challenges of creating and selling doujinshi, balancing his passion with his academic responsibilities.

The narrative delves into the dynamics of the doujinshi community, showcasing the diverse personalities and motivations of its members. Key characters include Mizuki Takase, a talented artist who becomes Kazuki's partner in creating doujinshi, and Yuu Inagawa, a cheerful and supportive friend who encourages Kazuki's endeavors. Other notable figures include Eimi Ohba, a professional manga artist who provides guidance, and Chisa Tsukamoto, a rival creator with a competitive streak.

As Kazuki immerses himself in the world of doujinshi, he faces various obstacles, such as tight deadlines, creative differences, and the pressures of competition. The series highlights the collaborative nature of doujinshi production, emphasizing the importance of teamwork and perseverance. It also touches on the personal growth of the characters as they pursue their artistic ambitions and form meaningful connections within the community.

"Comic Party" balances its focus on the creative process with moments of humor and lighthearted interactions among the characters. The series provides an insightful look into the doujinshi culture, offering a blend of slice-of-life storytelling and themes of artistic expression and camaraderie. Through its exploration of the challenges and rewards of creating doujinshi, the series captures the passion and dedication of its characters, making it a compelling portrayal of the creative journey.