"Monster Girl Doctor" is set in the fictional city of Lindworm, a bustling hub where humans and various monster species coexist. The narrative centers on Dr. Glenn Litbeit, a skilled and compassionate physician specializing in treating monster girls. His clinic, located in the heart of Lindworm, serves a diverse clientele, including lamias, centaurs, mermaids, and harpies, each with unique anatomical and medical needs. Assisting him is Sapphee, a lamia and his dedicated assistant, who harbors deep feelings for him.

The series unfolds through episodic medical cases, with each episode focusing on a different monster girl patient. Dr. Glenn's expertise and empathy are consistently highlighted as he diagnoses and treats ailments specific to each species, often requiring creative solutions due to their distinct physiologies. For instance, a mermaid suffering from dehydration due to her inability to return to the sea, or a centaur experiencing joint pain from overexertion, showcase the challenges of interspecies healthcare.

Interwoven with the medical cases are glimpses into the daily lives and relationships of the characters. Sapphee's unrequited love for Dr. Glenn adds a layer of personal drama, while interactions with other recurring characters, such as Tisalia, a proud centaur gladiator, and Lulala, a shy mermaid singer, enrich the world-building. The series also explores themes of coexistence, mutual respect, and the importance of understanding differences, as Dr. Glenn bridges the gap between humans and monsters through his work.

The setting of Lindworm is vividly portrayed as a vibrant, multicultural city where humans and monsters live side by side, each contributing to the community in their own way. The narrative emphasizes the harmony achieved through cooperation and the challenges of maintaining such a diverse society. Dr. Glenn's role as a healer extends beyond physical ailments, as he often provides emotional support and fosters trust between species.

"Monster Girl Doctor" balances its episodic medical drama with lighthearted moments and character-driven storytelling. The series avoids overt conflict, instead focusing on the day-to-day challenges and triumphs of its characters. Through its exploration of medical ethics, interspecies relationships, and the intricacies of a shared society, the series offers a unique blend of fantasy and slice-of-life elements, anchored by Dr. Glenn's unwavering dedication to his patients.