"Moeyo Ken" is a historical fantasy anime set in the late 19th century during Japan's Meiji Restoration, blending elements of action, comedy, and supernatural themes. The story revolves around the Shinsengumi, a group of samurai tasked with maintaining order in Kyoto, but with a twist: the central characters are reimagined as women. The protagonist, Toshie Hijikata, is a spirited and determined young woman who wields a magical sword capable of defeating supernatural entities. Alongside her are other female versions of historical Shinsengumi figures, including Saya Okita, a skilled swordswoman with a calm demeanor, and Kaoru Kondou, the group's strong and charismatic leader.

The narrative unfolds as the Shinsengumi face off against various supernatural threats, including yokai and other malevolent spirits, while also navigating the political turmoil of the era. The series balances intense action sequences with lighthearted comedic moments, often highlighting the camaraderie and quirks of the main characters. Toshie's journey is central to the plot, as she grapples with her responsibilities as a warrior and her personal growth. The anime incorporates historical elements, such as the Shinsengumi's role in the Bakumatsu period, but reinterprets them through a fantastical lens, blending real-world events with imaginative storytelling. The interplay between the characters, their distinct personalities, and their shared mission to protect Kyoto forms the core of the series, offering a mix of historical intrigue and supernatural adventure.