"Gakuen Alice" is a 26-episode anime series based on the manga by Tachibana Higuchi. The story centers around Mikan Sakura, a cheerful and somewhat clumsy 10-year-old girl, who transfers to Alice Academy, a prestigious and mysterious school for children with special abilities known as "Alices." Mikan's decision to enroll is driven by her desire to reunite with her best friend, Hotaru Imai, who was taken to the academy due to her exceptional talent in inventing.

At Alice Academy, students are categorized based on their unique abilities, which range from controlling fire to manipulating time. Mikan initially struggles to fit in, as her Alice is not immediately apparent. However, it is later revealed that she possesses the rare and powerful "Nullification Alice," which allows her to neutralize other Alices. This ability draws both admiration and suspicion from her peers and teachers.

The narrative explores Mikan's journey as she navigates the challenges of the academy, forms new friendships, and uncovers the darker aspects of the institution. Key characters include Natsume Hyuuga, a brooding and powerful student with a dangerous "Fire Alice," and his twin sister, Aoi, who harbors a deep resentment toward Mikan. Ruka Nogi, another prominent student with a "Pheromone Alice," becomes a close ally and love interest for Mikan. The series also delves into the complex dynamics between the students and the academy's enigmatic headmaster, Narumi, who has his own hidden agenda.

As the story progresses, Mikan and her friends uncover secrets about the academy's true purpose, including its involvement in unethical experiments and the exploitation of students' Alices. The series balances lighthearted moments of school life with darker themes of betrayal, loss, and the struggle for autonomy. Mikan's unwavering optimism and determination to protect her friends serve as the emotional core of the narrative, driving the plot toward its resolution.

The anime concludes with Mikan and her peers confronting the academy's corrupt leadership and fighting to reclaim their freedom, setting the stage for potential future developments. "Gakuen Alice" blends elements of fantasy, drama, and comedy, offering a compelling exploration of friendship, identity, and the consequences of power.