"Resident Evil: Damnation" is a CGI animated film set in the "Resident Evil" universe, focusing on Leon S. Kennedy, a U.S. government agent, as he investigates a civil war in the Eastern European country of Eastern Slav Republic. The conflict involves the use of bio-organic weapons (BOWs), specifically the Licker and Tyrant models, deployed by both government and rebel forces. Leon infiltrates the war-torn region to uncover the source of these BOWs and assess the threat they pose globally.

The narrative begins with Leon observing the escalating violence in Eastern Slav Republic, where the government, led by President Svetlana Belikova, accuses rebel leader Igor of using BOWs to destabilize the nation. Leon's mission becomes more complex when he encounters Ada Wong, a mysterious operative with her own agenda, and Buddy, a local rebel fighter who aids Leon in navigating the chaos. As Leon delves deeper, he discovers that the government is also complicit in the production and deployment of BOWs, using them to maintain control over the population.

The plot intensifies when Leon uncovers a secret underground facility where the BOWs are being developed and tested. The facility houses a powerful Tyrant, codenamed "Plaga Type 3," which is controlled by a parasitic organism. Leon and Buddy confront the Tyrant in a climactic battle, while Ada Wong manipulates events from the shadows to secure valuable data on the BOWs for her employers. The film concludes with Leon successfully destroying the facility and halting the immediate threat, though the broader implications of BOW proliferation remain unresolved.

Key characters include Leon S. Kennedy, portrayed as a seasoned and resourceful agent; Ada Wong, whose motives remain ambiguous but who plays a critical role in the unfolding events; and Buddy, a rebel fighter whose personal vendetta against the government adds emotional depth to the story. The film explores themes of political corruption, the ethics of bioweapon development, and the human cost of warfare, all set against the backdrop of the "Resident Evil" franchise's signature blend of action and horror.