"Resident Evil: Infinite Darkness" is a four-episode anime series set in the "Resident Evil" universe, blending survival horror with political intrigue. The story takes place in 2006, six years after the Raccoon City incident, and follows Leon S. Kennedy and Claire Redfield as they confront a new bioterrorism threat. Leon, now a federal agent working for the U.S. government, is called to investigate a hacking incident at the White House. Simultaneously, Claire, a TerraSave humanitarian worker, uncovers disturbing evidence of a viral outbreak while assisting war refugees in Penamstan. Their paths converge when a mysterious zombie outbreak occurs in the White House, revealing a conspiracy tied to a covert U.S. military operation in Penamstan.

The narrative explores themes of government corruption and the ethical implications of bioweapon development. Leon and Claire discover that the outbreak is linked to a secret project involving the T-virus, orchestrated by rogue elements within the U.S. government. The project aimed to create bioweapons for geopolitical dominance, but the experiments spiraled out of control, leading to the outbreak. Key figures in the conspiracy include Jason, a former U.S. soldier who becomes a rogue operative after being exposed to the virus, and Wilson, a high-ranking government official manipulating events to cover up the operation.

Leon and Claire work separately but share a common goal of exposing the truth. Leon’s investigation leads him to confront Jason, who has mutated into a monstrous form due to the virus. Claire, meanwhile, uncovers documents implicating Wilson and attempts to bring the evidence to light. The series culminates in a tense confrontation aboard a decommissioned aircraft carrier, where Leon battles Jason’s mutated form and Claire narrowly escapes assassination attempts by Wilson’s operatives. Despite their efforts, the conspiracy remains largely hidden from the public, with Wilson continuing to manipulate events to protect his interests.

The series maintains a focus on the partnership and shared history between Leon and Claire, though their interactions are limited. It expands the "Resident Evil" lore by delving into the political ramifications of bioterrorism and the moral ambiguity of those in power. The plot is driven by action sequences, investigative elements, and the recurring threat of viral outbreaks, staying true to the franchise’s core themes of survival and uncovering hidden truths.