Akira Takizawa, a young man, wakes up in front of the White House in Washington, D.C., with no memory of his identity. He is naked, holding a gun and a cell phone loaded with 8.2 billion yen in digital currency. The phone connects him to a mysterious operator named Juiz, who assists him in carrying out requests. Akira encounters Saki Morimi, a Japanese woman on her graduation trip, and the two form a bond as they navigate the strange circumstances surrounding him. Akira learns he is one of twelve individuals, known as "Seleção," chosen to participate in a game to save Japan from societal collapse. Each Seleção is given access to vast resources and must use them to implement their vision for the country's future.

The story shifts between Akira's efforts to uncover his past and the broader game orchestrated by an enigmatic figure known as Mr. Outside. Akira discovers he was involved in a missile attack on Tokyo, though he cannot recall his role in the event. As he investigates, he encounters other Seleção, each with their own agendas and methods for reshaping Japan. Some seek to exploit the system for personal gain, while others aim to enact radical societal changes. Akira's approach is more altruistic, focusing on helping individuals and addressing systemic issues.

Saki becomes a key ally, providing emotional support and aiding Akira in his quest. The narrative explores themes of identity, responsibility, and the impact of technology on society. Akira's journey is marked by moments of tension, humor, and introspection as he grapples with his forgotten past and the moral implications of the game. The series also delves into the lives of other Seleção, revealing their motivations and the consequences of their actions.

The plot builds toward a climactic confrontation as Akira uncovers the truth about his involvement in the missile attack and the identity of Mr. Outside. The resolution ties together the personal and societal threads of the story, offering a thought-provoking conclusion. "Eden of the East" combines elements of mystery, thriller, and social commentary, presenting a narrative that is both engaging and thematically rich. The characters are well-developed, with Akira and Saki serving as compelling protagonists whose relationship evolves throughout the series. The story's exploration of contemporary issues and its intricate plot structure make it a standout entry in the anime genre.