"Angel Tales" is a 12-episode anime series that blends elements of fantasy, romance, and comedy. The story centers around Goro Mutsumi, a young man who has experienced a series of unfortunate events in his life, including the loss of his parents and a string of failed relationships. On his 20th birthday, Goro is visited by a mysterious figure named Chitose, who reveals that Goro is the reincarnation of a celestial being. Chitose explains that Goro’s past life was marked by kindness and compassion, and as a result, he is granted the opportunity to reunite with twelve guardian spirits who were once his loyal companions in the celestial realm.

These guardian spirits, known as the "Angel Tales," are reincarnated as twelve girls, each representing a different animal from the Chinese zodiac. Each girl possesses unique traits and abilities tied to their zodiac sign, and they are tasked with protecting and supporting Goro in his current life. The girls include characters such as Natsume (Rat), Tsubasa (Ox), Kurumi (Tiger), and others, each embodying distinct personalities and dynamics with Goro. As the series progresses, Goro navigates his relationships with these girls, balancing their affection and loyalty while uncovering the deeper connections they share from their past lives.

The narrative unfolds through episodic interactions, with each episode focusing on one or more of the guardian spirits and their efforts to reconnect with Goro. Themes of friendship, loyalty, and the bonds of past lives are explored as Goro gradually regains memories of his celestial existence. The series incorporates lighthearted comedic moments alongside emotional undertones, particularly as Goro and the girls confront challenges that test their unity and resolve. While the overarching plot is driven by the reunion of Goro and his guardian spirits, the series also delves into the individual struggles and growth of each character, highlighting their unique contributions to Goro’s life and their shared destiny.