"3×3 Eyes" is a supernatural adventure manga series written and illustrated by Yuzo Takada, serialized from 1987 to 2002. The story revolves around the immortal Sanjiyan Unkara, a three-eyed being from a race known as the Sanjiyan, who possess immense power and longevity. The narrative begins with Yakumo Fujii, a young man living in Tokyo, who encounters Pai, a mysterious girl with a third eye on her forehead. Pai is the last surviving member of the Sanjiyan race and seeks to become human by collecting the scattered pieces of a powerful artifact known as the "Eye of the Beast."

Pai's quest is driven by her desire to shed her immortality and experience human emotions, a goal tied to her tragic past. Yakumo becomes entangled in her journey after being accidentally transformed into an immortal zombie-like creature called a Wu. As a Wu, Yakumo is bound to Pai, sharing her immortality and serving as her protector. Together, they travel across the world, facing supernatural threats, ancient conspiracies, and powerful adversaries who seek the Eye of the Beast for their own purposes.

The series explores themes of immortality, identity, and the human condition, as Yakumo grapples with his new existence and Pai struggles with her dual nature as both a powerful Sanjiyan and a vulnerable girl yearning for humanity. Their relationship evolves from one of necessity to a deep bond, as they confront their shared destiny and the consequences of their actions.

Key characters include Pai, whose innocence and determination drive the narrative; Yakumo, whose resilience and loyalty make him a compelling protagonist; and various antagonists, such as the demonic Kaiyanwang, who seeks to use the Eye of the Beast to dominate the world. The story is marked by its intricate world-building, blending elements of mythology, horror, and action, as well as its exploration of the moral and emotional complexities of immortality.

The manga's episodic structure allows for a mix of standalone adventures and overarching plotlines, culminating in a climactic battle that resolves the central conflict while leaving room for reflection on the characters' journeys. "3×3 Eyes" is notable for its blend of dark fantasy and emotional depth, making it a standout work in the supernatural genre.