"Hell Teacher: Jigoku Sensei Nube" centers on Meisuke Nueno, a fifth-grade teacher at Domori Elementary School, who harbors a supernatural secret. His left hand is a demonic claw, a result of a curse from his childhood, granting him the ability to exorcise evil spirits and protect his students from malevolent forces. Despite his monstrous hand, Nueno, affectionately called Nube by his students, is a kind-hearted and dedicated educator who balances his teaching duties with his role as a spiritual protector.

The series intertwines episodic supernatural cases with overarching character development. Each episode typically features Nube and his students encountering various yokai, ghosts, or cursed phenomena. These encounters often stem from unresolved human emotions, societal issues, or ancient legends, blending horror, comedy, and moral lessons. Nube’s students, particularly Miki Hosokawa and Ritsuko Takahashi, frequently assist him, showcasing their growth and bravery as they face otherworldly threats.

Nube’s backstory is gradually revealed, detailing his childhood and the origins of his demonic hand. His mentor, Isao Hyuga, plays a significant role in shaping his abilities and moral compass. The narrative also explores Nube’s relationships with his colleagues, including Yukime, a snow spirit who becomes a recurring ally, and Hiroshi Tateno, a fellow teacher who often finds himself entangled in supernatural incidents.

The series balances lighthearted school life with darker, more intense moments, creating a unique blend of genres. Nube’s dual role as a teacher and exorcist highlights themes of responsibility, compassion, and the importance of confronting one’s fears. The episodic structure allows for a variety of supernatural tales, while recurring characters and plot threads provide continuity and depth to the overarching narrative.