"My Next Life as a Villainess: All Routes Lead to Doom! X" is the second season of the anime adaptation of the light novel series by Satoru Yamaguchi. The story continues the adventures of Catarina Claes, a noblewoman who retains memories of her past life as a Japanese high school student. In her previous life, she recalls playing a dating simulation game called "Fortune Lover," in which the character she now embodies, Catarina, is the villainess destined for exile or death depending on the player's choices. Determined to avoid her fate, Catarina works to alter the game's narrative by befriending the main characters and navigating the complex social dynamics of her world.

The second season delves deeper into the relationships Catarina has cultivated with the game's key characters, including her fiancé, Geordo Stuart, his brother Alan Stuart, her childhood friend Keith Claes, the noblewoman Mary Hunt, the mage Nicol Ascart, his sister Sophia Ascart, and the commoner Maria Campbell. As Catarina continues to interact with them, her genuine kindness and obliviousness to romantic advances create comedic and heartfelt moments. The narrative explores new challenges, such as the introduction of a mysterious new character, Sora, who claims to be Maria's long-lost brother. Sora's arrival adds tension and intrigue, as his motives remain unclear, and his presence threatens to disrupt the balance of Catarina's carefully maintained relationships.

The plot also introduces a magical academy arc, where Catarina and her friends attend a prestigious school for nobles and commoners alike. This setting allows for further exploration of the characters' backgrounds and relationships, as well as the societal tensions between different classes. Catarina's efforts to avoid her doom remain central, but her actions inadvertently lead to new complications, as her influence continues to reshape the game's original storyline. The season balances humor, romance, and light drama, maintaining the charm of the first season while expanding on the world and its characters. The narrative concludes with Catarina's fate still uncertain, leaving room for further development in potential future installments.