"Girls und Panzer" is set in a world where tank warfare is a traditional sport practiced by girls at high schools. The story centers on Miho Nishizumi, a student at Ooarai Girls' Academy, who initially avoids participating in Sensha-do, the art of tank combat, due to a traumatic past involving her family's strict adherence to the Nishizumi style of tankery. However, after learning that her school is at risk of closure due to financial difficulties, Miho reluctantly agrees to lead her school's tankery team in a national tournament to save Ooarai.

The narrative unfolds as Miho and her classmates form a tankery team, despite their lack of experience and resources. They gather a diverse group of students, each contributing unique skills and personalities, and begin training with outdated and mismatched tanks. The team includes characters like the energetic and determined Saori Takebe, the calm and resourceful Hana Isuzu, the eccentric and mechanically inclined Yukari Akiyama, and the pragmatic and level-headed Mako Reizei. Together, they navigate the challenges of teamwork, strategy, and competition.

As the tournament progresses, the Ooarai team faces off against various schools, each with its own specialized tactics and tank models. The matches are intense and strategic, showcasing the importance of coordination, quick thinking, and adaptability. Miho's leadership and tactical acumen gradually earn the respect of her teammates and opponents alike. The series highlights the growth of the characters as they overcome personal insecurities and learn to trust one another.

The story also delves into Miho's strained relationship with her family, particularly her older sister Maho, who is a top tank commander at the prestigious Kuromorimine Girls' Academy. Their interactions reveal the pressures of legacy and the differing philosophies on tankery, adding depth to Miho's character and her journey. The final match against Kuromorimine serves as a climactic showdown, testing the limits of Ooarai's teamwork and Miho's resolve.

"Girls und Panzer" combines elements of sports anime with military strategy, creating a unique blend of action, camaraderie, and character development. The series emphasizes the importance of perseverance, creativity, and unity, as the Ooarai team strives to prove themselves against more experienced and well-equipped opponents. The narrative is driven by the characters' personal growth and their shared goal of preserving their school, making it a compelling and engaging story.