"Cat's Eye" is a crime-adventure anime series centered around the Kisugi sisters—Rui, Hitomi, and Ai—who lead double lives as art thieves and café owners. By day, they run the Cat's Eye café, a popular spot in Tokyo, but by night, they execute meticulously planned heists to steal priceless artworks. Their primary motivation is to recover paintings left by their missing father, Michael Heinz, a renowned artist who disappeared under mysterious circumstances. Each stolen piece holds a clue to his whereabouts, and the sisters believe that assembling the collection will reveal the truth behind his disappearance.

The series unfolds as the sisters target specific artworks, often encountering obstacles in the form of law enforcement, rival thieves, and personal dilemmas. Their primary adversary is Toshio Utsumi, a dedicated and sharp-witted detective who is determined to capture the elusive Cat's Eye thieves. Unbeknownst to him, Hitomi, the middle sister, is also his romantic interest, adding a layer of tension and complexity to their interactions. Utsumi's relentless pursuit of the thieves is driven by his sense of justice, but his growing feelings for Hitomi create a moral conflict that challenges his professional resolve.

The narrative is structured around episodic heists, with each episode focusing on a specific artwork and the challenges the sisters face in acquiring it. The series balances action, humor, and drama, often delving into the sisters' personal lives and their emotional connection to their father's legacy. The dynamic between the siblings is a key element, showcasing their teamwork, resourcefulness, and unwavering loyalty to one another. Rui, the eldest, is the strategic leader; Hitomi, the middle sister, is the skilled driver and markswoman; and Ai, the youngest, is the tech-savvy expert who handles gadgets and disguises.

As the story progresses, the stakes escalate, with the sisters uncovering deeper secrets about their father's past and the true significance of the artworks they are collecting. The series maintains a steady pace, blending episodic adventures with an overarching mystery that ties the narrative together. The interplay between the sisters' dual identities, their relationship with Utsumi, and their quest for the truth creates a compelling and engaging storyline that appeals to fans of crime, mystery, and character-driven drama.