"Ojamajo Doremi" is a magical girl anime series that revolves around Doremi Harukaze, an ordinary elementary school girl who stumbles upon the secret that her grumpy neighbor, Majorika, is a witch. After accidentally turning Majorika into a frog-like creature, Doremi is tasked with becoming a witch apprentice to restore her. Doremi is joined by her friends Hazuki Fujiwara and Aiko Senoo, who also become witch apprentices, forming a trio of young girls learning magic under Majorika's reluctant guidance. The series explores their journey as they balance their magical training with everyday challenges, such as school, friendships, and family.

The narrative is episodic, with each episode focusing on the girls using magic to help others or solve problems, often learning valuable life lessons in the process. Their magical abilities grow as they progress through the ranks of witch apprentices, facing trials and earning magical items like the Magical Stage and the Magical Top. The series introduces additional characters, such as Onpu Segawa, a rival witch apprentice, and Momoko Asuka, a younger girl who later joins their group. The witches-in-training also encounter other magical beings, including fairies and fellow witches, who provide guidance or present obstacles.

As the story progresses, the girls face more complex challenges, including confronting their own insecurities and dealing with the consequences of misusing magic. The series delves into themes of responsibility, empathy, and personal growth, as the characters mature both as witches and individuals. The later seasons introduce darker and more emotional storylines, such as the revelation of Majorika's past and the struggles of other witches, adding depth to the narrative. Throughout the series, the bond between the girls remains central, emphasizing the importance of friendship and teamwork in overcoming adversity.