"Love Hina" centers on Keitaro Urashima, a young man who fails his college entrance exams and is subsequently disowned by his family. Seeking refuge, he moves to his grandmother's inn, Hinata House, only to discover it has been converted into an all-female dormitory. Despite initial resistance from the residents, Keitaro is allowed to stay as the manager, a role he reluctantly accepts. The series explores his interactions with the diverse group of women living at Hinata House, each with distinct personalities and backgrounds.

Naru Narusegawa, a fiery and athletic girl, becomes a central figure in Keitaro's life. Their relationship is marked by frequent misunderstandings and comedic clashes, though a deeper connection gradually develops. Other residents include Shinobu Maehara, a shy and skilled cook; Motoko Aoyama, a serious kendo practitioner with a disdain for men; Kaolla Su, a mischievous foreign exchange student with a penchant for inventing gadgets; and Mitsune "Kitsune" Konno, a laid-back and cunning woman who often stirs up trouble.

As Keitaro navigates his responsibilities and relationships, he learns of a childhood promise he made to a girl to attend Tokyo University together. This promise becomes a driving force for his determination to pass the entrance exams, despite repeated failures. The series blends romantic comedy with elements of slapstick humor, as Keitaro's earnest but clumsy nature leads to numerous chaotic situations. Over time, the characters grow closer, and their individual struggles and aspirations are revealed, adding depth to the narrative.

The story also incorporates moments of drama and introspection, particularly as Keitaro and Naru confront their feelings for each other. The series balances its comedic tone with heartfelt moments, exploring themes of perseverance, friendship, and self-discovery. Through its episodic structure, "Love Hina" builds a cohesive narrative that culminates in a resolution of Keitaro's academic and romantic pursuits, offering a satisfying conclusion to the characters' journeys.