"Is It Wrong to Try to Pick Up Girls in a Dungeon?: Arrow of the Orion" is a standalone anime film set in the world of Orario, where adventurers form Familia under gods and goddesses to explore the labyrinthine Dungeon. The story centers on Bell Cranel, a young adventurer from the Hestia Familia, who is known for his rapid growth and unwavering determination. Bell’s journey takes a dramatic turn when he encounters Artemis, a goddess who has descended to the mortal realm. Artemis recruits Bell and his companions, including the swordswoman Ais Wallenstein and the supporter Liliruca Arde, for a mission to defeat a powerful monster known as the Antares.

The narrative unfolds as Bell and his allies travel to the ancient ruins of the Kingdom of Olario, where the Antares is said to reside. Along the way, Bell forms a close bond with Artemis, who reveals her tragic past and her connection to the monster. The Antares, a creature of immense power, is revealed to be a manifestation of Artemis’s grief and guilt over the loss of her beloved companion, Orion, centuries ago. As the group confronts the Antares, Bell must grapple with the moral dilemma of destroying a being tied to Artemis’s emotions while also protecting the world from its destructive potential.

The film explores themes of sacrifice, duty, and the complexities of divine and mortal relationships. Bell’s growth as an adventurer is tested as he faces the emotional weight of Artemis’s story and the physical challenges of battling the Antares. The climax sees Bell and Artemis working together to confront the monster, culminating in a poignant resolution that underscores the bond between gods and mortals. The supporting cast, including Hestia, Ais, and Liliruca, play crucial roles in the mission, providing both strategic support and emotional depth to the narrative. The film maintains a balance between action, character development, and the exploration of its mythological setting, offering a self-contained story within the broader "DanMachi" universe.