"Dr. Stone: New World" continues the story of Senku Ishigami and his companions as they strive to rebuild civilization after a mysterious event petrifies humanity for thousands of years. The narrative picks up with Senku and his allies, including the scientifically inclined Chrome, the strong-willed Kohaku, and the resourceful Taiju, advancing their mission to revive humanity and uncover the secrets behind the petrification. Their primary goal is to create a revival fluid capable of restoring petrified individuals, a task that requires gathering rare materials and overcoming numerous challenges.

The story expands as Senku and his team set out on a voyage across the ocean to explore new territories, encountering unfamiliar environments and potential threats. This journey introduces new characters, such as the enigmatic and technologically advanced inhabitants of the "Island of the West," who possess knowledge and resources that could accelerate Senku's plans. However, these new allies and adversaries also bring complications, as conflicting ideologies and power struggles emerge. The series delves into themes of cooperation, innovation, and the ethical implications of scientific progress, as Senku balances his ambition with the need to protect his friends and humanity's future.

Key plot points include the development of advanced technologies, such as communication devices and transportation methods, which are crucial for uniting scattered human settlements. The narrative also explores the origins of the petrification event, hinting at a larger conspiracy that ties into humanity's past and future. As Senku and his team face natural disasters, rival factions, and internal conflicts, they must rely on their ingenuity and teamwork to overcome obstacles and move closer to their ultimate goal of restoring civilization. The series maintains a focus on problem-solving and scientific discovery, blending action, humor, and emotional moments to create a compelling and dynamic story.