"My Hero Academia THE MOVIE: World Heroes' Mission" is the third feature film in the "My Hero Academia" franchise, set within the timeline of the main series. The story centers on Izuku Midoriya (Deku), Katsuki Bakugo, and Shoto Todoroki as they embark on a high-stakes mission to save the world from a global threat. The narrative begins with Deku interning at a hero agency in the fictional country of Otheon, where he is falsely accused of mass murder after a terrorist attack. The attack is orchestrated by the villainous organization Humarise, which seeks to eradicate Quirks—the superhuman abilities possessed by most of the world's population—by releasing a deadly toxin.

As Deku evades capture, he teams up with Rody Soul, a local thief with a mysterious past, who becomes an unlikely ally. Meanwhile, Bakugo and Todoroki are dispatched by their agency to investigate Humarise's activities, leading them to uncover the organization's plan to unleash the Quirk-destroying toxin on a global scale. The trio eventually reunites, combining their strengths to infiltrate Humarise's headquarters and prevent the catastrophe. The film explores themes of heroism, sacrifice, and the moral complexities of a world defined by Quirks, while delivering intense action sequences and emotional character moments. The climax features a dramatic showdown between the heroes and Humarise's leader, Flect Turn, whose Quirk reflects attacks, posing a unique challenge for Deku and his allies. The resolution underscores the importance of unity and perseverance in the face of overwhelming adversity.