"One Piece: Episode of Skypiea" is a condensed retelling of the Skypiea arc from the original "One Piece" series, focusing on the Straw Hat Pirates' journey to the floating island of Skypiea. The story begins with the crew discovering a map to Skypiea, a legendary island in the sky, and setting out to reach it. After overcoming the perilous Knock Up Stream, they arrive in the sky world, where they encounter the native Shandians, the ruling god Enel, and the mysterious city of gold, Shandora.

The Straw Hat Pirates—Monkey D. Luffy, Roronoa Zoro, Nami, Usopp, Sanji, Tony Tony Chopper, and Nico Robin—become embroiled in a conflict between the Shandians, who seek to reclaim their ancestral land, and Enel, a self-proclaimed god who rules Skypiea with his priests. Enel plans to destroy Skypiea using his powerful Goro Goro no Mi abilities, which grant him control over lightning. Luffy, immune to Enel's lightning due to his rubber body, emerges as the key to stopping Enel's destructive ambitions.

The narrative explores themes of freedom, justice, and the clash between belief systems, as the Straw Hats ally with the Shandians and other Skypiea residents to challenge Enel's tyranny. Key events include the discovery of the ancient Poneglyph in Shandora, which ties into the broader lore of the Void Century, and the climactic battle between Luffy and Enel. The arc concludes with the defeat of Enel, the preservation of Skypiea, and the Straw Hats continuing their journey with newfound knowledge and treasures.

The retelling maintains the core elements of the original arc while streamlining the narrative for a more concise viewing experience, making it accessible to both new and returning audiences. The focus remains on the Straw Hat Pirates' camaraderie, their determination to protect their friends, and their unwavering pursuit of adventure.